Miscellaneous Passerini Reaction for α-Acyloxy Carboxamide: Synthesis and Process Optimization Study

“Phase Transfer Catalyst” as additive was exposed to the Passerini three-component reactions and the influence of its accelerating effect on the reaction rate was studied concerning direct involvement of reactant molecules. For the rapid formation of diverse “α-acyloxycarboxamides” using passerini reaction, multicomponent reactions were employed using miscellaneous 2-(prop-2-ynyloxy) benzaldehyde with various aromatic acids and slightly non-polar fragment, i.e. 2-isocyano-2,3,3- trimethylbutane, and the representative molecule was characterized with DEPT-135 NMR technique.