An Efficient One-Pot, Multicomponent Synthesis of 1, 3-Thiazolidin-4- Ones Using L-Proline as Catalyst in Water

An efficient methodology for the synthesis of 1,3-thiazolidin-4-ones using L-Proline as catalyst under aqueous conditions has been developed. The one-pot, multicomponent reaction of aromatic/ heterocyclic aldehyde, aromatic amine and thioglycolic acid at room temperature give 1,3- thiazolidin-4-ones in moderate to good yields. Further, the current approach is notably greener than traditional methods, with an E-factor of 3.1 and an eco scale score of 96. The developed protocol offers several features, such as being simple, environmentally benign, energy-efficient, economic, mild conditions, shorter reaction time.