Flufenamic Acid-Promoted the Coupling of Epoxides and CO2 to Form Cyclic Carbonates

The process of hydrogen bond donor accelerating the cycloaddition of epoxides with CO2 is a green conversion. In this text, commercial drug flufenamic acid which contains O-H and N-H groups is introduced to promote the coupling. The reaction is capable of tolerating a relatively wide range of groups with the aid of catalytic system flufenamic acid/TBAB. Moreover, the reaction mechanism is proposed on the basis of reported literatures.