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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water
- Source: Letters in Organic Chemistry, Volume 18, Issue 8, Aug 2021, p. 634 - 639
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- 01 Aug 2021
Abstract
An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).
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