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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Simple and Efficient Protocol for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones Catalyzed by Succinic Acid Using Water as Green Reaction Medium
- Source: Letters in Organic Chemistry, Volume 18, Issue 2, Feb 2021, p. 83 - 87
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- 01 Feb 2021
Abstract
A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium. This method is useful for the preparat ion of various derivatives of 3,4-disubstituted isoxazol-5(4H)-ones in excellent yields.
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