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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Simple Synthesis of the Anticancer Drug Altretamine
- Source: Letters in Organic Chemistry, Volume 17, Issue 8, Aug 2020, p. 628 - 630
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- 01 Aug 2020
Abstract
A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.
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