A Novel Copper-Catalyzed Synthesis of N-Monosubstituted 2-Alkynimidamides from 1-Alkynes and Trichloroacetamidines

A one-pot Cu-catalyzed synthesis of functionalized alkynyl imidamide by terminal alkynes, trichloroacetonitrile and aniline or benzyl amine is reported. The compounds were produced via coupling reaction of terminal alkynes with trichloroacetamidine. This method was performed under mild, ligand-free conditions and easy work-up method.