Pd-Catalyzed Carbonylation-cyclization of N′-(2-bromophenyl)benzamidines by Chloroform as a CO Precursor for the Synthesis of Quinazolin-4(3H)-ones

We present an efficient method for the synthesis of quinazolin-4(3H)-ones via Pdcatalyzed carbonylation-cyclization of N′-(2-bromophenyl)benzamidines. Chloroform cleanly generated CO under mild conditions. This method allows for the carbonylation-cyclization of N′-(2- bromophenyl)benzamidines in the presence of Pd(OAc)2 to give quinazolin-4(3H)-ones in good to excellent yields.