K2CO3 Promoted Cascade Reaction for the Preparation of 1H-Imidazol-4-yl-1-amine Derivatives

A K2CO3 promoted efficient one pot two-step method for the preparation of 1H-imidazol-4- yl-1-amine derivatives has been developed. A series of second amines with an imidazole group were obtained with 56%-91% yields by the K2CO3 promoted amination of acetates and nitrogen deprotection of the imidazole process.