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Eight new 2-(1H-indol-3-yl)-N-(aryl)-2-oxoacetamide amine based indole derivatives were synthesized. Microanalytical data, 1HNMR, 13CNMR, FT-IR and XRD were used to characterize the synthesized derivatives. The indole derivatives had also been screened for their nematicidal activity against root-knot nematode Meloidogyne incognita. Chlorine substituted indole derivatives had shown significant nematicidal activity comparative to other indole derivatives.