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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent
- Source: Letters in Organic Chemistry, Volume 15, Issue 9, Sep 2018, p. 801 - 804
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- 01 Sep 2018
Abstract
A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.
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