A Direct Access to N-Arylation of Guanidines by Ligand-Free, Copper Catalysis at Room Temperature

The copper (I)-catalyzed cross-coupling reactions between aryl halides and guanidines to produce N-aryl guanidines have been developed. Mild reaction conditions, good yields, ligand-free, easy work-up, no column chromatography, and ease of handling at room temperature are the main aspects of the method.