Graphene Oxide Catalyzed C-N/C-S/[3+2] Cyclization Cascade for Green Synthesis of Thiazolidinone in Water

In this paper, first graphene oxide catalyzed one-pot three-component green synthesis of 1,3- thiazolidin-4-one using amine, aldehyde and mercapto acetic acid in water has been reported. The reaction is affected via sequential C-N and C-S bond formation and ring transformation reactions leading to thiazolidin-4-ones formation. The use of water as solvent at room temperature, good to excellent yields of pure products (75-92%) and operational simplicity are the salient features of the envisaged protocol. The graphene oxide catalyst is very mild, effective and most of its activity is preserved after being reused for five times.