Expeditious and Green Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Catalyzed by Nano-MgO

An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanocrystalline magnesium oxide (nano-MgO) as a catalyst from 2-aminobenzamide and various aldehydes/ketones under aqueous conditions at room temperature is described. Nano-MgO was synthesized by the precipitation and hydrothermal treatment of aqueous salt solution as reported previously. The structure of nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. Simple conditions, environmentally benign, good to excellent yields and comparatively shorter reaction times are the advantages of this protocol.