Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β- Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway

A tandem metal-free synthesis of partly and fully substituted pyrimidines has been accomplished from α,β-unsaturated ketones and benzamidine in presence of triethyl amine. The reaction proceeds via [3+3] annulation-oxidation sequence and the protocol has been found successful for the synthesis of a wide range of pyrimidine derivatives.