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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Facile and Efficient Synthesis of Spiro[indoline-3,5`-pyrido[2,3-d] pyrimidine] Derivatives via Microwave-assisted Multicomponent Reactions
- Source: Letters in Organic Chemistry, Volume 12, Issue 1, Jan 2015, p. 62 - 66
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- 01 Jan 2015
Abstract
A facile and efficient synthesis of spiro[indoline-3,5'-pyrido[2,3-d]pyrimidine] derivatives by one-pot reactions of isatins, 2,6-diaminopyrimidin-4-one or 6-aminopyrimidine-2,4-dione and malononitrile under microwave irradiation conditions was investigated. This protocol has the virtue of short reaction time, high yields and easy work-up procedure.
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