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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of 3-substituted Coumarins: An Efficient Green Approach Using L-proline as Catalyst in Triethanolamine Medium
- Source: Letters in Organic Chemistry, Volume 11, Issue 8, Oct 2014, p. 556 - 563
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- 01 Oct 2014
Abstract
3-Substituted coumarins were synthesized very efficiently, using Knoevenagel method from salicylaldehydes 1 and active methylene compounds 2 under green conditions. The effect of catalyst and solvent on this condensation was studied. L-proline was found to be the best catalyst and triethanolamine the best reaction medium for this reaction.
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