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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Catalyst Free One-pot Three-component Synthesis of 2-Amino-4Hchromene Derivatives in Aqueous Deep Eutectic Mixture at Room Temperature
- Source: Letters in Organic Chemistry, Volume 11, Issue 7, Aug 2014, p. 480 - 486
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- 01 Aug 2014
Abstract
Multifunctional chromenes have been efficiently synthesized in aqueous medium at room temperature using deep eutectic mixture of choline chloride:urea. In this one-pot synthesis, the benzylidenemalononitrile firstly formed by Knoevenagel condensation of aldehyde and malononitrile eventually underwent Michael addition-cyclization with dimedone and offered the chromenes in good to excellent yield.
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