The synthesis and NMR properties of boron analogues of nucleotides and cyclic nucleotides

The routes of synthesis of the new boron nucleosides – 3’,5’-cyclic boron esters of 2’-deoxycytidine, 2’- deoxyuridine and thymidine along with 3’,5’-bis(pinacolborate) derivatives of 2’-deoxyuridine, 5-fluoro-2’-deoxyuridine and thymidine are presented. The 1H-, 13C- and 11B NMR data of new boron nucleosides are compared with their precursors NMR properties. Presented compounds are in fact boron analogs of nucleotides where boron is in the position of phosphorus atom. New compounds should be at interesting positions as new building blocks in nucleoside and nucleotide chemistry.