Full text loading...
- ISSN: 1570-1786
- E-ISSN: 1875-6255
-
A Facile Total Synthesis of Neurotrophic Metabolite (+/-)-Neuchromenin
- Source: Letters in Organic Chemistry, Volume 11, Issue 3, Mar 2014, p. 194 - 196
-
- 01 Mar 2014
Abstract
The synthesis of (+/-)-neuchromenin, a known natural product that induces neurite outgrowth of PC12 cells, is described. The total synthesis involved constructing a chromone ring from sesamol and coupling this intermediate to an aldehyde by a Morita-Baylis-Hillman reaction (MBH). The MBH adduct was cyclized under acidic conditions followed by removal of a methylene group to afford (+/-)-neuchromenin in 9 steps from sesamol.
© Bentham Science Publishers