The Synthesis of Enantiomers of 6-tert-Butyl-6-methylmorpholine-2,5- dione Using Wang Resin Supported Mukaiyama Reagent

The synthesis of enantiomers of 6-tert-butyl-6-methylmorpholine-2,5-dione (3) using Wang resin supported 2- chloro- or 2-bromo- pyridinium triflate is described. The applied methodology could be considered as an interesting alternative to “classical” one and enables the synthesis of 6-tert-butyl-6-methylmorpholine-2,5-dione with higher yields and the isolation of product (3) is significantly easier.