Total Synthesis of Diversified 1,2-disubstituted Benzimidazoles with Green Approach at Room Temperature

A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are easily recyclable, the method presented is very suitable for scale-up production. Furthermore, products were obtained in high yield and easily isolated making this method very practical and attractive.