Synthesis, Characterization and Antibacterial Activity of Cyclic Sulfamide Linked to Tetrathiafulvalene (TTF)

We herein describe the synthesis and antibacterial activity of cyclic sulfamide linked to tetrathiafulvalene (TTF). This approach exploits the inherent chemistry of biomolecules and π-donors compounds to generate symmetric bis-trimethyltetrathiafulvalenyl-2-thiophenyl cyclic sulfamides. Two strategies are revealed, one centres on the Ringclosing olefin metathesis using the Grubbs catalyst a second strategy based on the direct alkylation of dibromoalkane derivatives with symmetric sulfamide under basic conditions. All the newly synthesized compounds were screened for their antimicrobial activities and some of them were found to possess good or moderate antimicrobial activity.