Synthesis, Characterization and Biological Evaluation Against Influenza Virus Agonists of (N'E,N'"E)-2,2'-[[1,1'-Biphenyl]-4,4'-dihylbis(oxy)]bis (N'-arylmethyleneacetohydrazides)

N',N"'-[2,2'-[[1,1'-Biphenyl]-4,4'-diylbis(oxy)]bis(acetyl)]di(benzohydrazide) 3 was prepared by reaction of 2,2'-[1,1'-biphenyl]-4,4'-diylbis(oxy)]bisacetohydrazide 2 with benzoyl chloride. A new series of the arylidene 4-15 was prepared by heating 2 with the following aldehydes: 4-flourobenzaldehyde, p-tolualdehyde, 2-hydroxy-3- methoxybenzaldehyde, 2-chlorobenzaldehyde, isonicotinaldehyde (4-pyridine carboxaldehyde), benzaldehyde, 4- chlorobenzaldehyde, picolinaldehyde (2-pyridine carboxaldehyde), 4-methoxybenzaldehyde (4-anisaldehyde), 3- bromobenzaldehyde, 2,4,6-trimethoxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde (vaniline). The compounds were evaluated against influenza virus. Two compounds showed moderate activity which means that with more derivatization, better activity could be expected.