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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Conversion of Phenols into Aryl Tert-Butyl Ethers Under Mitsunobu Conditions Utilizing Neighboring Group Contribution
- Source: Letters in Organic Chemistry, Volume 10, Issue 1, Jan 2013, p. 2 - 7
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- 01 Jan 2013
Abstract
Under Mitsunobu conditions N-Boc-2-(hydroxymethyl)piperidine acts as a source of tert-butyl residue for the conversion of phenols into aryl tert-butyl ethers under neutral conditions. This reactivity can be attributed to a neighboring group contribution which strongly depends on the structure of the employed N-Boc-aminoalcohol. Five other, closely related N-Boc-aminoalcohols investigated here did not show this special reactivity, and gave the regular Mitsunobu coupling products.
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