An Efficient Catalyst System for the Synthesis of N-(p-benzoylaminoaryl)- N'-Boc Piperazines Under Microwave Conditions

We have developed a new combination of catalyst system for the synthesis of N-(p-benzoylaminoaryl)-N'-Boc piperazines under microwave conditions (Biotage, 300 Watt) in the presence of sodium tert-butoxide and in DMF. The catalyst and ligand used are Tris (dibenzylideneacetone) dipalladium(0) and 2-Dicyclohexylphosphino-2'-(N,Ndimethylamino) biphenyl (Dave Phos) respectively, the desired N-(p-benzoylaminoaryl)-N'-Boc Piperazines was obtained in good yields (80-92%).