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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Practical Synthesis and X-ray Crystallographic Analysis of Dithymoquinone, a Photodimer of Thymoquinone
- Source: Letters in Organic Chemistry, Volume 9, Issue 10, Dec 2012, p. 762 - 766
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- 01 Dec 2012
Abstract
An updated and practical approach to the synthesis of dithymoquinone via one-step photoirradiation of thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone) is described. Synthesis resulted in a 55 % yield of one structural isomer (trans-anti derivative), as confirmed by HPLC, NMR spectroscopy and first ever single-crystal X-ray diffraction analyses.
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