Enantioselective Addition of Diethylzinc to Aldehydes by Chiral Oxazolidine–Titanium Complex

A series of chiral oxazolidines derived from (1R, 2S)-cis-1-amino-2-indanol was found to be effective in promoting the asymmetric addition of diethylzinc to aldehydes. Among the ligands developed, it was found that ligand 1b in the presence of Ti(OiPr)4 yielded the highest enantioselectivities when it was applied in the catalytic asymmetric addition of diethylzinc to aldehydes (up to 91% ee).