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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages
- Source: Letters in Organic Chemistry, Volume 9, Issue 2, Feb 2012, p. 106 - 113
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- 01 Feb 2012
Abstract
Oligonucleotide analogs with L- and D-lysine residues incorporated in internucleotide linkages were synthesized and their affinity toward complementary DNA was studied. Stability of the duplexes formed by the modified oligonucleotides and their wild-type complements appeared to be close to that of the isosequential unmodified duplex, oligonucleotides carrying D-lysine residues forming generally more stable duplexes than L-lysine derivatives.
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