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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Study of the Regio- and Stereoselectivity of [3+2] Cycloaddition of Nitrile Oxides to Various Racemic 3-acyloxy and 3-hydroxybut-1-enes
- Source: Letters in Organic Chemistry, Volume 9, Issue 2, Feb 2012, p. 96 - 100
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- 01 Feb 2012
Abstract
1,3-Dipolar cycloadditions of aryl nitrile oxides 2d-f to various racemic 3-hydroxy- and 3-acyloxy-but-1-enes 1a-c proceeded with complete regioselectivity to afford the corresponding 3,5-disubstituted isoxazolines in good yields. The steric and/or electronic effect of an acyloxy group at the allylic position on the stereoselectivity has been studied.
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