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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis of 3-Aroylcoumarin-Flavone Hybrids
- Source: Letters in Organic Chemistry, Volume 9, Issue 3, Mar 2012, p. 218 - 220
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- 01 Mar 2012
Abstract
A facile two step synthesis of 3-aroylcoumarin-flavone hybrids was achieved from 7-hydroxyflavone and α- oxoketene dithioacetals. In the first step 7-hydroxyflavone was regioselectively formylated under Duff reaction conditions. Resulting 8-formyl-7-hydroxy flavones were condensed with α-oxoketene dithioacetals in the presence of a catalytic amount of piperidine to furnish 3-aroylcoumarin-flavone hybrids.
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