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2000
Volume 9, Issue 3
  • ISSN: 1570-1786
  • E-ISSN: 1875-6255

Abstract

Benzylamine in combination with acetic acid was identified as a powerful catalyst for the condensation of oxindole with aldehydes, acetone or cyclic ketones. A variety of 3-alkyloxindoles could be readily prepared in 10 mmol scale via the sequential benzylamine acetate catalyzed condensation of oxindoles with aldehydes (or ketones) and conjugate reduction by NaBH4.

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/content/journals/loc/10.2174/157017812800167420
2012-03-01
2025-09-30

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  • Article Type:     Research Article
Keyword(s): 3-alkenyloxindoles; 3-alkyloxindoles; alkylation; amination; arylation; benzylamine; carbonyl compounds; conjugate reduction; Knoevenagel condensations; oxindoles

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