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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Efficient Synthesis of β-Acetamido Ketones Catalyzed by Cobalt Sulfate Heptahydrate Under Ultrasound Irradiation
- Source: Letters in Organic Chemistry, Volume 9, Issue 1, Jan 2012, p. 45 - 50
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- 01 Jan 2012
Abstract
Ultrasound-promoted synthesis of β-acetamido ketones catalyzed by cobalt sulfate heptahydrate via one-pot multi-component reaction coupling of aromatic aldehyde, acetophenone and acetyl chloride in acetonitrile was carried out in excellent yields at 25-28 °C, providing an efficient synthesis of these compounds. The use of ultrasound increased the rate of reactions compared with reactions under reflux condition.
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