Three Component Condensation Reaction as an Efficient Route for the Synthesis of Furo[2,3-d]pyrimidines

The condensation reactions of alkyl isocyanides with 1,3-dimethylbarbituric acid and aryl carboxaldehydes to afford 6-(alkylamino)-5-(3-aryl)-1,3-dimethylfuro[2,3-d]pyrimidine-2,4(1H,3H)-dione, in excellent yields under neutral conditions, are reported.