Full text loading...
- ISSN: 1570-1786
- E-ISSN: 1875-6255
-
Synthesis, Structural Determination of a New Ocotillol Derivative and its Epimer
- Source: Letters in Organic Chemistry, Volume 8, Issue 9, Nov 2011, p. 682 - 685
-
- 01 Nov 2011
Abstract
Epimeric 20S, 24-epoxy-dammarane-3β, 6α, 12β, 25-tetraol acetic ester was synthesized from 20(S)- protopanaxatriol in the presence of acetic anhydride and the product oxidated by m-CPBA. 20S, 24R-epoxy dammarane- 3β, 6α, 12β, 25-tetraol (ocotillol derivative) and its epimer were synthesized by saponification in the presence of sodium hydroxide in 1:1 molar ratio. The structures of the two compounds were characterized by X-ray diffraction method. The results showed the configuration of C-24 of two epimers as S-form (4, ocotillol derivative) and R-form (3, epimer), respectively.
© Bentham Science Publishers