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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Highly Efficient, Chemoselective Syntheses of 2-Methoxy-4-substituted Pyrimidines
- Source: Letters in Organic Chemistry, Volume 8, Issue 8, Oct 2011, p. 545 - 548
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- 01 Oct 2011
Abstract
Three 2-methoxy-4-substituted pyrimidine compounds were chemoselectively synthesized by diazotization, using 2,4-dichloropyrimidine as the starting material. In nonaqueous diazotization reaction system, halo-substituted 6 and 7 were efficiently prepared, and in aqueous medium, hydrolysis product 8 was afforded.
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