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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Synthesis and Biological Evaluation of Novel Indolin-2-One Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors
- Source: Letters in Organic Chemistry, Volume 8, Issue 7, Sep 2011, p. 526 - 530
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- 01 Sep 2011
Abstract
3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class of protein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range. Compound 36, the lowest, bore an IC50 value of 3.48 µ M. Preliminary structure-activity relationship was summarized.
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