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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Highly Efficient Synthesis of β-Amino Ketones via Direct Mannich-type Reaction Catalyzed by Acidic Ionic Liquid
- Source: Letters in Organic Chemistry, Volume 8, Issue 6, Jul 2011, p. 385 - 390
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- 01 Jul 2011
Abstract
[MPSIm]+CF3COO- ionic liquid is an efficient green catalyst for the one-pot, three-component Mannich-type reaction of aromatic aldehydes, aromatic amines and cyclohexanone. The reaction was completed within 5-60 min to give the corresponding β-amino ketones in 82-98% yield at room temperature. The catalyst can be recycled at least four times without significant decrease in activity.
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