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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Novel Synthesis of Ibutilide Fumarate
- Source: Letters in Organic Chemistry, Volume 8, Issue 6, Jul 2011, p. 423 - 426
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- 01 Jul 2011
Abstract
A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.
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