Synthesis of (±) Travoprost and its Analogs

Harikrishna Mudduluru; Rama M. Hindupur; Pramod K. Dubey; Shankar Madhavaram; Lakshmikumar Tatini; Gottumukkala V. Subbaraju

doi:10.2174/157017811795371485

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis of (±) Travoprost and its Analogs
By Harikrishna Mudduluru, Rama M. Hindupur, Pramod K. Dubey, Shankar Madhavaram, Lakshmikumar Tatini and Gottumukkala V. Subbaraju
Source: Letters in Organic Chemistry, Volume 8, Issue 4, May 2011, p. 234 - 241
DOI: https://doi.org/10.2174/157017811795371485
- Available online: 01 May 2011

Abstract

A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth-Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.

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2011-05-01

2025-09-30

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Article Type: Research Article

Keyword(s): (±) travoprost; alkylation; antiglaucoma; dimethoxyethane; dimethyl; methane; n-BuLi; phosphonate; Phosphonate; Prostaglandins

Synthesis of (±) Travoprost and its Analogs

Abstract

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