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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Solvent-Free Biginelli Reaction: A Green Method for the Synthesis of 3,4-Dihydropyrimidin-2-ones Catalyzed by Protic Acids in Large-Scale
- Source: Letters in Organic Chemistry, Volume 8, Issue 4, May 2011, p. 264 - 267
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- 01 May 2011
Abstract
An environmentally benign Biginelli reaction for the large-scale preparation of substituted 3,4- dihydropyrimidin-2(1H)-ones using protic acids as a catalyst has been achieved. These mechanochemical reactions proceed efficiently in the absence of organic solvent, with the assistance of infrared lamp irradiation.
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