Multicomponent Reactions Stereo- and Regioselective Three-Component Reaction in Water: Synthesis of Triazole Substituted β-Lactams Via Click Chemistry

Three-component reaction in water was used to prepare a series of triazole substituted trans-β-lactams from the corresponding trans-4-acetoxy-lactam, sodium azide, and alkynes via a Cu(I)-catalyzed click chemistry with base free. This highly stereo- and regioselective procedure is simple, clean and efficient.