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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III
- Source: Letters in Organic Chemistry, Volume 7, Issue 6, Sep 2010, p. 450 - 452
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- 01 Sep 2010
Abstract
A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10- deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.
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