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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Metal Triflates: Efficient Catalysts for Oxa-Pictet-Spengler Reaction
- Source: Letters in Organic Chemistry, Volume 7, Issue 6, Sep 2010, p. 420 - 423
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- 01 Sep 2010
Abstract
A screening of different metal triflates as catalysts was performed to get isochromans through an oxa-Pictet- Spengler reaction. Good to high yields were obtained for various aliphatic or aromatic aldehydes and β-arylethanols. A mechanism involving catalysis by in situ liberated triflic acid to catalyse the isochroman ring formation is proposed.
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