Novel dihydropyrazole Derivatives Linked with 4H-Chromene: Microwave-Promoted Synthesis and Antibacterial Activity

Seven novel 6-(1-acetyl-3-methyl-4,5-dihydro-1H-pyrazol-5-yl)-2-amino-4-substituted-phenyl-4H-chromene- 3-carbonitrile derivatives were synthesized and characterized by ESI-MS, 1H NMR and 13C NMR. All of the compounds have been screened for their antibacterial activity. The results show that compounds 7e and 7f displayed significant activity with MIC of 1.562 μg/mL against B. subtilis ATCC 6633.