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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate
- Source: Letters in Organic Chemistry, Volume 7, Issue 4, Jun 2010, p. 311 - 313
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- 01 Jun 2010
Abstract
A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.
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