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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Triethylamine Promoted Efficient Synthesis of 3,4-Dihydropyrimidin- 2(1H)-ones/thiones Using a Solvent-Free Biginelli Condensation
- Source: Letters in Organic Chemistry, Volume 7, Issue 4, Jun 2010, p. 272 - 276
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- 01 Jun 2010
Abstract
An efficient and simple protocol has been developed for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones by a one-pot three-component cyclocondensation reaction of an aromatic aldehyde, β-ketoester, and urea or thiourea under solvent-free conditions using triethylamine (Et3N) as catalyst for the Biginelli reaction.
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