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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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The First Kinetic Enzymatic Resolution of Methyl Ester of C75
- Source: Letters in Organic Chemistry, Volume 7, Issue 3, Apr 2010, p. 245 - 248
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- 01 Apr 2010
Abstract
Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with >99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-(-)-C75 with >99% e.e.
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