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- ISSN: 1570-1786
- E-ISSN: 1875-6255
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Phase-Transfer Catalysed Enantioselective Epoxidation of Estra-Δ5(10),9(11)-diene Using Chiral Ammonium Salts Derived from Cinchona Alkaloids
- Source: Letters in Organic Chemistry, Volume 7, Issue 2, Mar 2010, p. 163 - 167
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- 01 Mar 2010
Abstract
A modified phase-transfer catalysed enantioselective epoxidation of estra-Δ5(10),9(11)-diene, an important intermediate of anti-early pregnancy drug mifepristone 1, have been determined and investigated. Eight chiral ammonium salts (PTC A-H), used as phase-transfer catalysts, have been synthesized from cinchona alkaloids. Among them, PTC G and PTC H have exhibited satisfying catalytic activity to improve the ratio of α/β epoxide up to 7:1.
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