Full text loading...
- ISSN: 1570-1786
- E-ISSN: 1875-6255
-
A Diphenylprolinol TMS Ether/Bile Acid Organocatalytic System for the Asymmetric Domino Sulfa-Michael/Aldol Condensation Reactions of 1,4-Dithiane-2,5-diol and Cinnamaldehydes
- Source: Letters in Organic Chemistry, Volume 6, Issue 8, Dec 2009, p. 593 - 597
-
- 01 Dec 2009
Abstract
Organocatalytic asymmetric domino sulfa-Michael/aldol condensation reactions between 1,4-dithiane-2,5-diol (the dimer of mercaptoacetaldehyde) and cinnamaldehydes were efficiently promoted by (S)-diphenylprolinol TMS ether in the presence of bile acid derivatives, leading to hitherto unknown 4,5-dihydrothiophene-2-carbaldehydes in moderate to good yields and good enantioselectivities.
© Bentham Science Publishers